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pentobarbital will reduce the level or impact of aprepitant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can reduce panobinostat degrees by ~70% and result in procedure